Pathology and virus dispersion in cynomolgus monkeys experimentally infected with severe acute respiratory syndrome coronavirus via different inoculation routes

Pathology and virus dispersion in cynomolgus monkeys experimentally infected with severe acute respiratory syndrome coronavirus via different inoculation routes

Source :

• International Journal of Experimental Pathology [ 0959-9673 ] ; 2007-12.

Descripteurs français

• KwdFr :
  • Animaux, Antigènes viraux (analyse), Cytométrie en flux, Facteur de nécrose tumorale alpha (immunologie), Génome viral, Injections, Injections veineuses, Interleukine-12 (immunologie), Interleukine-8 (immunologie), Macaca fascicularis, Macrophages (virologie), Macrophages alvéolaires (virologie), Maladies transmissibles émergentes (immunologie), Maladies transmissibles émergentes (transmission), Maladies transmissibles émergentes (virologie), Modèles animaux, Mâle, Poumon (immunologie), Poumon (virologie), RT-PCR, Rectum (virologie), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (transmission), Technique d'immunofluorescence indirecte, Tissu lymphoïde (virologie), Trachée, Virus du SRAS (génétique), Virus du SRAS (pathogénicité).
• MESH :
  • analyse : Antigènes viraux.
  • génétique : Virus du SRAS.
  • immunologie : Facteur de nécrose tumorale alpha, Interleukine-12, Interleukine-8, Maladies transmissibles émergentes, Poumon, Syndrome respiratoire aigu sévère.
  • pathogénicité : Virus du SRAS.
  • virologie : Animaux, Cytométrie en flux, Génome viral, Injections, Injections veineuses, Macaca fascicularis, Macrophages, Macrophages alvéolaires, Maladies transmissibles émergentes, Modèles animaux, Mâle, Poumon, RT-PCR, Rectum, Syndrome respiratoire aigu sévère, Technique d'immunofluorescence indirecte, Tissu lymphoïde, Trachée.

English descriptors

• KwdEn :
  • Animals, Antigens, Viral (analysis), Communicable Diseases, Emerging (immunology), Communicable Diseases, Emerging (transmission), Communicable Diseases, Emerging (virology), Flow Cytometry, Fluorescent Antibody Technique, Indirect, Genome, Viral, Injections, Injections, Intravenous, Interleukin-12 (immunology), Interleukin-8 (immunology), Lung (immunology), Lung (virology), Lymphoid Tissue (virology), Macaca fascicularis, Macrophages (virology), Macrophages, Alveolar (virology), Male, Models, Animal, Rectum (virology), Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (genetics), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (transmission), Trachea, Tumor Necrosis Factor-alpha (immunology).
• MESH :
  • chemical , analysis : Antigens, Viral.
  • genetics : SARS Virus.
  • immunology : Communicable Diseases, Emerging, Interleukin-12, Interleukin-8, Lung, Severe Acute Respiratory Syndrome, Tumor Necrosis Factor-alpha.
  • pathogenicity : SARS Virus.
  • transmission : Communicable Diseases, Emerging, Severe Acute Respiratory Syndrome.
  • virology : Communicable Diseases, Emerging, Lung, Lymphoid Tissue, Macrophages, Macrophages, Alveolar, Rectum.
• Teeft :
  • Alveolar macrophages, Animal experiments, Animals, Assay, Authors journal compilation, Blackwell publishing, Cell numbers, Coronavirus, Cynomolgus, Cynomolgus monkeys, Cytokine, Experimental pathology, Flow Cytometry, Fluorescent Antibody Technique, Indirect, Genome, Genome, Viral, Germinal centre, High levels, Histopathological, Histopathological changes, Hong kong, Human sars, Infectious diseases, Infectious virus, Injections, Injections, Intravenous, Inoculated, Inoculation, Inoculation route, International journal, Intestinal, Intestinal tissues, Intragastric, Intratracheal, Intravenous, Isolation rectal, Lower lobe, Lung lesions, Lung wash, Lymph, Lymph nodes, Lymphatic systems, Macaca fascicularis, Macrophage, Male, Models, Animal, Monkey, Monkeys inoculated, Nagata, Nasal, Nasal cavity, National institute, Node, Novel coronavirus, Pathogenesis, Peiris, Peribronchial, Peribronchial lymph node, Peribronchial lymph nodes, Rectal, Rectal mucosa, Rectal swabs, Replication, Respiratory syndrome, Respiratory syndrome coronavirus, Respiratory tract, Reverse Transcriptase Polymerase Chain Reaction, Sars, Sars patients, Second inoculation, Swab, Syndrome, Trachea, Viral, Viral genome, Virus, Virus cells, Virus genome, Virus infection.

Abstract

• https://api.istex.fr/ark:/67375/WNG-77CWR355-B/fulltext.pdf
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517337

Affiliations:

• Japon
• Région de Kantō
• Tokyo

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